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Scientists Improve Cervical Cancer Prediction With New Test | The Optimist Daily

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Great news! A more accurate test for cell changes that can lead to cervical cancer has just been developed by scientists.

The groundbreaking test can also detect DNA markers for some other common cancers, implying that it could be used as a predictive test for breast, womb, cervical, and ovarian cancer in the future.

The researchers behind the test previously demonstrated that by using cervical cells from a routine smear test, they may be able to detect or predict the development of ovarian and breast cancer.

The expert team has now revealed that when used to screen for cervical cancer, the new test outperforms current methods in identifying women with advanced cell changes who require treatment.

How much better is the new test?

It detected 55% of those who would have cell changes in the next four years in those who did not have cell changes but had human papillomavirus (HPV), which causes the majority of cases of cervical cancer. The findings were published in Genome Medicine.

“This new method is more specific and doesn’t lead to over-treatment, which is good news for cervical cancer prevention and great news for everyone who needs to be screened,” said Athena Lamnisos, the chief executive of the Eve Appeal charity.

“It’s so welcome to see screening tools and predictive tests becoming more effective. We want to prevent cancer – and we know with cervical cancer that we can intervene at an early stage.”

Each year, approximately 3,200 new cases of cervical cancer are diagnosed in the UK alone, with approximately 850 deaths. Half of all women with the disease live for ten years or longer.

How does the new test work?

Experts led by the University of Innsbruck and University College London (UCL) examined DNA methylation, which acts as an extra layer of information on top of DNA, in their most recent study.

DNA contains all of the genes that people inherit from both parents, whereas DNA methylation instructs cells on which bits of DNA to read.

Smoking, pollution, a poor diet, and being overweight can all alter these markers and alter how the cell behaves. Scientists believe they can detect cancer and possibly predict someone’s risk of developing cancer in the future by closely studying DNA methylation.

The new study included 1,254 cervical screening samples from women who had cell changes ranging from low to high risk, women who had HPV but no cervical cell changes, and samples from women who had no cervical cell changes but developed high-risk cell changes within four years.

“Vaccination against the virus that causes cervical cancer is now widely implemented and is leading to changes in the amount and types of virus circulating in the community,” said Prof Martin Widschwendter of UCL’s department of women’s cancer. As a result, the approaches to cervical screening must evolve in order for programs to continue to be beneficial.

“Building new, holistic, risk-predictive screening programs around existing, effective cervical sample collection offers real potential for cancer prevention in the future.”

Source study: Genome Medicine— The WID-CIN test identifies women with and at risk of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

The post Scientists improve cervical cancer prediction with new test first appeared on The Optimist Daily: Making Solutions the News.

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The Therapy School For Children Raised In Delhi’s Red Light District

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Overcoming Loneliness: 4 Ways To Make Real Connections And Build Community | The Optimist Daily

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Have you ever considered how your brain interprets loneliness? Surprisingly, it recognizes it as a threat. Loneliness is more than simply a passing mood; it is a major risk factor for a variety of health problems. Loneliness can have serious consequences for our health, including sadness, anxiety, heart disease, and premature mortality. Some research indicates that it is as dangerous as smoking 15 cigarettes per day.

Why are we facing a loneliness epidemic?

Loneliness is a universal human feeling, but its prevalence increased in recent years, particularly during the COVID-19 pandemic. With prolonged periods of seclusion becoming the norm, many Americans are experiencing the long-term repercussions of social disengagement. However, it is not just the epidemic to blame; technology also plays an important role. With more than half of Americans spending more than half of their time online, meaningful face-to-face contact has become increasingly rare, compounding feelings of loneliness.

How loneliness impacts mental health

Loneliness is not only emotionally draining; it is also physically harmful. According to research, lonely people frequently have elevated amounts of inflammatory markers in their brains, which can lead to a variety of health problems. Furthermore, loneliness can trigger our bodies’ “fight or flight” reaction, increasing paranoia and susceptibility to illness. The stakes are high, as loneliness has been linked to an increased risk of dementia, heart disease, stroke, and early mortality.

4 ways to take action against loneliness

Are you feeling overwhelmed with loneliness? You are not alone. Here are four practical suggestions to help you rediscover a sense of connection and well-being in your life.

The power of reaching out

Taking the first step can be frightening, but reaching out to someone can make a huge difference. Desiring a sense of closeness is normal. The best way to get there is by taking the initiative to reach out to someone. Connecting with people, whether through a simple text message to a friend or talking with a neighbor, can help reduce feelings of loneliness and foster new friendships.

Prioritizing in-person connections

In today’s digital age, it’s easy to become lost in the virtual world. However, spending too much time online might amplify feelings of loneliness. Instead, aim to restrict your screen time and promote in-person connections. Face-to-face connections, whether through a coffee date with a buddy or participation in a local organization or class, can bring a much-needed sense of belonging and purpose.

Finding purpose by volunteering

Did you realize that giving back might improve your mental health? Volunteering not only helps you to make a positive difference in your community, but it also provides possibilities for social interaction and connection. Volunteering has been shown to reduce stress, improve emotional well-being, and even benefit our physical health. Whether you’re interested in environmental protection or helping local charities, volunteering may be a gratifying approach to combat loneliness while also making a difference in the world.

Seeking support for lasting solutions

If feelings of loneliness linger, seek professional help. Speaking with a health care expert, such as a therapist or psychologist, can provide helpful support, advice, and coping skills for loneliness. They can also assist uncover any underlying issues that may be contributing to your feelings of isolation and propose appropriate interventions based on your specific needs.

While there is no quick treatment for loneliness, you may take measures to increase meaningful connections and support in your life. Reaching out to people, emphasizing in-person interaction, volunteering, and seeking professional help as needed can help you break free from loneliness and embrace a life of purpose and connection.

The post Overcoming loneliness: 4 ways to make real connections and build community  first appeared on The Optimist Daily: Making Solutions the News.

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Successful Gene-Hacked Pig Kidney Transplant Shows Promise In Xenotransplantation | The Optimist Daily

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A team at Massachusetts General Hospital in Boston performed a breakthrough surgical accomplishment, transplanting a kidney from a gene-hacked pig into a 62-year-old man. Richard Slayman, a patient who suffered from kidney illness for almost a decade, emerged from the hospital with renewed optimism and health. 

“This moment—leaving the hospital today with one of the cleanest bills of health I’ve had in a long time—is one I wished would come for many years,” expressed Slayman in an official statement.

His transplanted kidney, created by biotech company eGenesis, is operating well, marking a big victory for xenotransplantation.

The promise of xenotransplantation

Xenotransplantation, or the process of transferring organs from one species to another, has enormous potential for alleviating the current shortage of human donor organs. David Klassen, chief medical officer of the United Network for Organ Sharing who was not involved in the surgery, emphasizes that this development can potentially benefit a large number of patients. 

“Though much work remains to be done, I think the potential of this to benefit a large number of patients will be realized, and that was a question mark hovering over the field,” he says. He hopes that these advancements will reduce the load on the organ donation system and provide life-saving treatments to individuals in need by using genetically engineered pig organs.

Overcoming challenges and uncertainties

Slayman’s successful operation is cause for excitement, but hurdles and uncertainty remain. The possibility of organ rejection exists, as Slayman’s immune system may still see the pig kidney as foreign. However, the rapid reversal of initial rejection symptoms with treatment provides a glimpse of optimism. Furthermore, the scalability and reproducibility of this technique have yet to be determined, raising concerns regarding its wider applicability to varied patient populations.

The future of organ transplantation

Despite these difficulties, the consequences of Slayman’s procedure are significant. With over 100,000 Americans waiting for human donor transplants each year and only a minority receiving them, demand significantly outstrips supply. By adopting xenotransplantation, we can change the field of organ transplantation, providing hope to many people on transplant waiting lists. Slayman’s rehabilitation journey is still ongoing, but his tale serves as a light of hope for sufferers around the world.

As Slayman begins his post-transplant journey, he is continuously followed and supported by medical personnel. His experience demonstrates the potential of innovation in medicine. With ongoing research and improvements in xenotransplantation, we are on the verge of a transformative age in healthcare.

The post Successful gene-hacked pig kidney transplant shows promise in xenotransplantation  first appeared on The Optimist Daily: Making Solutions the News.

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