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Scientists Improve Cervical Cancer Prediction With New Test | The Optimist Daily

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Great news! A more accurate test for cell changes that can lead to cervical cancer has just been developed by scientists.

The groundbreaking test can also detect DNA markers for some other common cancers, implying that it could be used as a predictive test for breast, womb, cervical, and ovarian cancer in the future.

The researchers behind the test previously demonstrated that by using cervical cells from a routine smear test, they may be able to detect or predict the development of ovarian and breast cancer.

The expert team has now revealed that when used to screen for cervical cancer, the new test outperforms current methods in identifying women with advanced cell changes who require treatment.

How much better is the new test?

It detected 55% of those who would have cell changes in the next four years in those who did not have cell changes but had human papillomavirus (HPV), which causes the majority of cases of cervical cancer. The findings were published in Genome Medicine.

“This new method is more specific and doesn’t lead to over-treatment, which is good news for cervical cancer prevention and great news for everyone who needs to be screened,” said Athena Lamnisos, the chief executive of the Eve Appeal charity.

“It’s so welcome to see screening tools and predictive tests becoming more effective. We want to prevent cancer – and we know with cervical cancer that we can intervene at an early stage.”

Each year, approximately 3,200 new cases of cervical cancer are diagnosed in the UK alone, with approximately 850 deaths. Half of all women with the disease live for ten years or longer.

How does the new test work?

Experts led by the University of Innsbruck and University College London (UCL) examined DNA methylation, which acts as an extra layer of information on top of DNA, in their most recent study.

DNA contains all of the genes that people inherit from both parents, whereas DNA methylation instructs cells on which bits of DNA to read.

Smoking, pollution, a poor diet, and being overweight can all alter these markers and alter how the cell behaves. Scientists believe they can detect cancer and possibly predict someone’s risk of developing cancer in the future by closely studying DNA methylation.

The new study included 1,254 cervical screening samples from women who had cell changes ranging from low to high risk, women who had HPV but no cervical cell changes, and samples from women who had no cervical cell changes but developed high-risk cell changes within four years.

“Vaccination against the virus that causes cervical cancer is now widely implemented and is leading to changes in the amount and types of virus circulating in the community,” said Prof Martin Widschwendter of UCL’s department of women’s cancer. As a result, the approaches to cervical screening must evolve in order for programs to continue to be beneficial.

“Building new, holistic, risk-predictive screening programs around existing, effective cervical sample collection offers real potential for cancer prevention in the future.”

Source study: Genome Medicine— The WID-CIN test identifies women with and at risk of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

The post Scientists improve cervical cancer prediction with new test first appeared on The Optimist Daily: Making Solutions the News.

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Current news: Nanoparticles delivered past the Blood Brain Barrier

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The circus is coming to town…

Jon Rappoport Jan 31

The circus is coming to town. Your brain is the circus, and the town is the lab.

The nanoparticle elephants and lions and clowns they want to put in your brain are only a billionth of a meter in size. That’s right. If you stack 80,000 of the particles side by side, they add up to the width of a human hair.

But don’t worry. The scientists know what they’re doing. They have to. No one else does.

You’ll feel fine. Better than ever.

Because this is medical. And medical always works.

Ask a person over the age of 65 who was diagnosed with COVID after a phony useless test and sedated and put on a breathing ventilator in a hospital. You’ll have to reach into the afterlife to talk to him because the treatment killed him.

But that’s OK. Everything is OK.

Science Daily reports (Jan 19, 2023):

Gene therapies have the potential to treat neurological disorders like Alzheimer’s and Parkinson’s diseases, but they face a common barrier—the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain’s protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.

“There is no cure yet for many devastating brain disorders,” says Shaoqin “Sarah” Gong, UW-Madison professor of ophthalmology and visual sciences and biomedical engineering and researcher at the Wisconsin Institute for Discovery. “Innovative brain-targeted delivery strategies may change that by enabling noninvasive, safe and efficient delivery of CRISPR genome editors that could, in turn, lead to genome-editing therapies for these diseases.”

CRISPR is a molecular toolkit for editing genes (for example, to correct mutations that may cause disease), but the toolkit is only useful if it can get through security to the job site. The blood-brain barrier is a membrane that selectively controls access to the brain, screening out toxins and pathogens that may be present in the bloodstream. Unfortunately, the barrier bars some beneficial treatments, like certain vaccines and gene therapy packages, from reaching their targets because it lumps them in with hostile invaders…

In a study recently published in the journal Advanced Materials, Gong and her lab members, including postdoctoral researcher and first author of the study Yuyuan Wang, describe a new family of nano-scale capsules made of silica that can carry genome-editing tools into many organs around the body and then harmlessly dissolve.

By modifying the surfaces of the silica nanocapsules with glucose and an amino acid fragment derived from the rabies virus, the researchers found the nanocapsules could efficiently pass through the blood-brain barrier to achieve brain-wide gene editing in mice. In their study, the researchers demonstrated the capability of the silica nanocapsule’s CRISPR cargo to successfully edit genes in the brains of mice, such as one related to Alzheimer’s disease called amyloid precursor protein gene.

Because the nanocapsules can be administered repeatedly and intravenously, they can achieve higher therapeutic efficacy without risking more localized and invasive methods.

The researchers plan to further optimize the silica nanocapsules’ brain-targeting capabilities and evaluate their usefulness for the treatment of various brain disorders. This unique technology is also being investigated for the delivery of biologics to the eyes, liver and lungs, which can lead to new gene therapies for other types of disorders.

Uh-huh. Right. Sure. It’s all OK.

I hope you caught the part about sending GENE EDITORS into the brain to perform genetic procedures.

Early in my career, I worked with editors at newspapers and magazines. A number of them were grossly overweight. They wouldn’t fit in a brain.

But you see, THESE groundbreaking editors are nano-sized. A billionth of a meter. And they’re carrying editing tools with them on their belts.

The tools are called CRISPR. That’s the latest and greatest blade that cuts out offending genes.

Only one problem. A number of studies show CRISPR screws up. Particularly at the point where the cut is made. When the genes reconnect to eliminate the empty space that was created, the joining isn’t perfect.

Oops. And this has consequences. Bad consequences. The extent and nature of those new sloppy joinings are unpredictable. Think RIPPLE EFFECT.

That adds to the wildness of the circus in the brain.

You can’t really talk to those nanoparticle gene editors and ask them what went wrong. They don’t know. They’re only equipped to make their CRISPR cuts. Then they (supposedly) dissolve.

Did you also notice, in the Science Daily article above, the reference to delivering life-saving drugs and vaccines directly to the brain?

So now nanoparticle drug humpers will be added to the medical circus. Carrying, for example, vaxes like COVID, which are injuring and killing people across the world. And drugs which routinely kill at least 100,000 American patients every year.

But these consequences are just the cost of doing business behind the WOW super-technology that allows passage through the blood brain barrier.

This innovation is like drilling into a percolating volcano. You do it because you can. This is the guiding principle. When all hell breaks loose, because you just woke up the heat and the fire and the lava, you accept that.

Science marches on.

Stay tuned.

— Jon Rappoport

Episode 34 of Rappoport Podcasts—“We Are Living In the Era of Nanotechnology, Science Beyond Our Control; A Clear and Present Danger”—is now posted on my substack. It’s a blockbuster. To listen, click here. To learn more about This Episode of Rappoport Podcasts, click here.

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Life After: Miscarriage – Positive News

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The post Life after: Miscarriage appeared first on Positive News.

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How Black Barbers In London Are Giving Poor Mental Health The Chop

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