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Masahiro Sakurai Shows Off A Prototype Of The Game That Would Become Smash Bros.

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A screenshot of Dragon King: The Fighting Game, the game that would eventually become Super Smash Bros.
Image: Masahiro Sakurai

Masahiro Sakurai is a YouTuber now, and in his latest video, he showed off a “never-before-seen” clip of the prototype that would eventually become Super Smash Bros. You can feast your eyes on Dragon King: The Fighting Game beginning at 1:25 in the video at the top of this post or jump directly to that moment by clicking this link.

The Dragon King footage is clearly from an early stage of development, but you can already see elements that are now core to the Smash franchise, like percentages representing health, the iconic three-platform “Battlefield” stage layout, and characters flying off the edges of the screen to their deaths. Fighters were just polygonal humans — not Nintendo characters — and they could use moves like smash…

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Health

Current news: Nanoparticles delivered past the Blood Brain Barrier

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The circus is coming to town…

Jon Rappoport Jan 31

The circus is coming to town. Your brain is the circus, and the town is the lab.

The nanoparticle elephants and lions and clowns they want to put in your brain are only a billionth of a meter in size. That’s right. If you stack 80,000 of the particles side by side, they add up to the width of a human hair.

But don’t worry. The scientists know what they’re doing. They have to. No one else does.

You’ll feel fine. Better than ever.

Because this is medical. And medical always works.

Ask a person over the age of 65 who was diagnosed with COVID after a phony useless test and sedated and put on a breathing ventilator in a hospital. You’ll have to reach into the afterlife to talk to him because the treatment killed him.

But that’s OK. Everything is OK.

Science Daily reports (Jan 19, 2023):

Gene therapies have the potential to treat neurological disorders like Alzheimer’s and Parkinson’s diseases, but they face a common barrier—the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain’s protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.

“There is no cure yet for many devastating brain disorders,” says Shaoqin “Sarah” Gong, UW-Madison professor of ophthalmology and visual sciences and biomedical engineering and researcher at the Wisconsin Institute for Discovery. “Innovative brain-targeted delivery strategies may change that by enabling noninvasive, safe and efficient delivery of CRISPR genome editors that could, in turn, lead to genome-editing therapies for these diseases.”

CRISPR is a molecular toolkit for editing genes (for example, to correct mutations that may cause disease), but the toolkit is only useful if it can get through security to the job site. The blood-brain barrier is a membrane that selectively controls access to the brain, screening out toxins and pathogens that may be present in the bloodstream. Unfortunately, the barrier bars some beneficial treatments, like certain vaccines and gene therapy packages, from reaching their targets because it lumps them in with hostile invaders…

In a study recently published in the journal Advanced Materials, Gong and her lab members, including postdoctoral researcher and first author of the study Yuyuan Wang, describe a new family of nano-scale capsules made of silica that can carry genome-editing tools into many organs around the body and then harmlessly dissolve.

By modifying the surfaces of the silica nanocapsules with glucose and an amino acid fragment derived from the rabies virus, the researchers found the nanocapsules could efficiently pass through the blood-brain barrier to achieve brain-wide gene editing in mice. In their study, the researchers demonstrated the capability of the silica nanocapsule’s CRISPR cargo to successfully edit genes in the brains of mice, such as one related to Alzheimer’s disease called amyloid precursor protein gene.

Because the nanocapsules can be administered repeatedly and intravenously, they can achieve higher therapeutic efficacy without risking more localized and invasive methods.

The researchers plan to further optimize the silica nanocapsules’ brain-targeting capabilities and evaluate their usefulness for the treatment of various brain disorders. This unique technology is also being investigated for the delivery of biologics to the eyes, liver and lungs, which can lead to new gene therapies for other types of disorders.

Uh-huh. Right. Sure. It’s all OK.

I hope you caught the part about sending GENE EDITORS into the brain to perform genetic procedures.

Early in my career, I worked with editors at newspapers and magazines. A number of them were grossly overweight. They wouldn’t fit in a brain.

But you see, THESE groundbreaking editors are nano-sized. A billionth of a meter. And they’re carrying editing tools with them on their belts.

The tools are called CRISPR. That’s the latest and greatest blade that cuts out offending genes.

Only one problem. A number of studies show CRISPR screws up. Particularly at the point where the cut is made. When the genes reconnect to eliminate the empty space that was created, the joining isn’t perfect.

Oops. And this has consequences. Bad consequences. The extent and nature of those new sloppy joinings are unpredictable. Think RIPPLE EFFECT.

That adds to the wildness of the circus in the brain.

You can’t really talk to those nanoparticle gene editors and ask them what went wrong. They don’t know. They’re only equipped to make their CRISPR cuts. Then they (supposedly) dissolve.

Did you also notice, in the Science Daily article above, the reference to delivering life-saving drugs and vaccines directly to the brain?

So now nanoparticle drug humpers will be added to the medical circus. Carrying, for example, vaxes like COVID, which are injuring and killing people across the world. And drugs which routinely kill at least 100,000 American patients every year.

But these consequences are just the cost of doing business behind the WOW super-technology that allows passage through the blood brain barrier.

This innovation is like drilling into a percolating volcano. You do it because you can. This is the guiding principle. When all hell breaks loose, because you just woke up the heat and the fire and the lava, you accept that.

Science marches on.

Stay tuned.

— Jon Rappoport

Episode 34 of Rappoport Podcasts—“We Are Living In the Era of Nanotechnology, Science Beyond Our Control; A Clear and Present Danger”—is now posted on my substack. It’s a blockbuster. To listen, click here. To learn more about This Episode of Rappoport Podcasts, click here.

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Science and Tech

The Best Webcam To Buy Right Now

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Photo by Amelia Holowaty Krales / The Verge

You can get a great 1080p webcam for under $75. If you want to spend more, you can get 4K recording, AI head tracking, and even a real gimbal.

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Science and Tech

Where Are The Satellites, Samsung?

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Samsung S23 Plus in green shown in-hand with rear panel facing out.
Pictured: a phone that you can’t contact people with when you’re not near a cell tower. | Photo by Allison Johnson / The Verge

When Qualcomm announced its Snapdragon Satellite tech that will let Android phone makers compete with Apple’s Emergency SOS via satellite, I was almost certain we’d see the feature on Samsung’s then-upcoming S23 phones.

I mean, why wouldn’t we? Qualcomm said the feature would be available this year for phones using its Snapdragon 8 Gen 2 processor, and Samsung is launching the first big Android flagship of 2023 with that processor — surely, it’ll build in this potentially life-saving functionality, like analysts have been predicting for months.

And then Samsung’s Unpacked event came and went, with no mention of satellite messaging at all, and CNET posted an interview with TM Roh, president and head of Samsung’s mobile experience…

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