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Current news: Nanoparticles delivered past the Blood Brain Barrier

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The circus is coming to town…

Jon Rappoport Jan 31

The circus is coming to town. Your brain is the circus, and the town is the lab.

The nanoparticle elephants and lions and clowns they want to put in your brain are only a billionth of a meter in size. That’s right. If you stack 80,000 of the particles side by side, they add up to the width of a human hair.

But don’t worry. The scientists know what they’re doing. They have to. No one else does.

You’ll feel fine. Better than ever.

Because this is medical. And medical always works.

Ask a person over the age of 65 who was diagnosed with COVID after a phony useless test and sedated and put on a breathing ventilator in a hospital. You’ll have to reach into the afterlife to talk to him because the treatment killed him.

But that’s OK. Everything is OK.

Science Daily reports (Jan 19, 2023):

Gene therapies have the potential to treat neurological disorders like Alzheimer’s and Parkinson’s diseases, but they face a common barrier—the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain’s protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.

“There is no cure yet for many devastating brain disorders,” says Shaoqin “Sarah” Gong, UW-Madison professor of ophthalmology and visual sciences and biomedical engineering and researcher at the Wisconsin Institute for Discovery. “Innovative brain-targeted delivery strategies may change that by enabling noninvasive, safe and efficient delivery of CRISPR genome editors that could, in turn, lead to genome-editing therapies for these diseases.”

CRISPR is a molecular toolkit for editing genes (for example, to correct mutations that may cause disease), but the toolkit is only useful if it can get through security to the job site. The blood-brain barrier is a membrane that selectively controls access to the brain, screening out toxins and pathogens that may be present in the bloodstream. Unfortunately, the barrier bars some beneficial treatments, like certain vaccines and gene therapy packages, from reaching their targets because it lumps them in with hostile invaders…

In a study recently published in the journal Advanced Materials, Gong and her lab members, including postdoctoral researcher and first author of the study Yuyuan Wang, describe a new family of nano-scale capsules made of silica that can carry genome-editing tools into many organs around the body and then harmlessly dissolve.

By modifying the surfaces of the silica nanocapsules with glucose and an amino acid fragment derived from the rabies virus, the researchers found the nanocapsules could efficiently pass through the blood-brain barrier to achieve brain-wide gene editing in mice. In their study, the researchers demonstrated the capability of the silica nanocapsule’s CRISPR cargo to successfully edit genes in the brains of mice, such as one related to Alzheimer’s disease called amyloid precursor protein gene.

Because the nanocapsules can be administered repeatedly and intravenously, they can achieve higher therapeutic efficacy without risking more localized and invasive methods.

The researchers plan to further optimize the silica nanocapsules’ brain-targeting capabilities and evaluate their usefulness for the treatment of various brain disorders. This unique technology is also being investigated for the delivery of biologics to the eyes, liver and lungs, which can lead to new gene therapies for other types of disorders.

Uh-huh. Right. Sure. It’s all OK.

I hope you caught the part about sending GENE EDITORS into the brain to perform genetic procedures.

Early in my career, I worked with editors at newspapers and magazines. A number of them were grossly overweight. They wouldn’t fit in a brain.

But you see, THESE groundbreaking editors are nano-sized. A billionth of a meter. And they’re carrying editing tools with them on their belts.

The tools are called CRISPR. That’s the latest and greatest blade that cuts out offending genes.

Only one problem. A number of studies show CRISPR screws up. Particularly at the point where the cut is made. When the genes reconnect to eliminate the empty space that was created, the joining isn’t perfect.

Oops. And this has consequences. Bad consequences. The extent and nature of those new sloppy joinings are unpredictable. Think RIPPLE EFFECT.

That adds to the wildness of the circus in the brain.

You can’t really talk to those nanoparticle gene editors and ask them what went wrong. They don’t know. They’re only equipped to make their CRISPR cuts. Then they (supposedly) dissolve.

Did you also notice, in the Science Daily article above, the reference to delivering life-saving drugs and vaccines directly to the brain?

So now nanoparticle drug humpers will be added to the medical circus. Carrying, for example, vaxes like COVID, which are injuring and killing people across the world. And drugs which routinely kill at least 100,000 American patients every year.

But these consequences are just the cost of doing business behind the WOW super-technology that allows passage through the blood brain barrier.

This innovation is like drilling into a percolating volcano. You do it because you can. This is the guiding principle. When all hell breaks loose, because you just woke up the heat and the fire and the lava, you accept that.

Science marches on.

Stay tuned.

— Jon Rappoport

Episode 34 of Rappoport Podcasts—“We Are Living In the Era of Nanotechnology, Science Beyond Our Control; A Clear and Present Danger”—is now posted on my substack. It’s a blockbuster. To listen, click here. To learn more about This Episode of Rappoport Podcasts, click here.

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The Therapy School For Children Raised In Delhi’s Red Light District

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Overcoming Loneliness: 4 Ways To Make Real Connections And Build Community | The Optimist Daily

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Have you ever considered how your brain interprets loneliness? Surprisingly, it recognizes it as a threat. Loneliness is more than simply a passing mood; it is a major risk factor for a variety of health problems. Loneliness can have serious consequences for our health, including sadness, anxiety, heart disease, and premature mortality. Some research indicates that it is as dangerous as smoking 15 cigarettes per day.

Why are we facing a loneliness epidemic?

Loneliness is a universal human feeling, but its prevalence increased in recent years, particularly during the COVID-19 pandemic. With prolonged periods of seclusion becoming the norm, many Americans are experiencing the long-term repercussions of social disengagement. However, it is not just the epidemic to blame; technology also plays an important role. With more than half of Americans spending more than half of their time online, meaningful face-to-face contact has become increasingly rare, compounding feelings of loneliness.

How loneliness impacts mental health

Loneliness is not only emotionally draining; it is also physically harmful. According to research, lonely people frequently have elevated amounts of inflammatory markers in their brains, which can lead to a variety of health problems. Furthermore, loneliness can trigger our bodies’ “fight or flight” reaction, increasing paranoia and susceptibility to illness. The stakes are high, as loneliness has been linked to an increased risk of dementia, heart disease, stroke, and early mortality.

4 ways to take action against loneliness

Are you feeling overwhelmed with loneliness? You are not alone. Here are four practical suggestions to help you rediscover a sense of connection and well-being in your life.

The power of reaching out

Taking the first step can be frightening, but reaching out to someone can make a huge difference. Desiring a sense of closeness is normal. The best way to get there is by taking the initiative to reach out to someone. Connecting with people, whether through a simple text message to a friend or talking with a neighbor, can help reduce feelings of loneliness and foster new friendships.

Prioritizing in-person connections

In today’s digital age, it’s easy to become lost in the virtual world. However, spending too much time online might amplify feelings of loneliness. Instead, aim to restrict your screen time and promote in-person connections. Face-to-face connections, whether through a coffee date with a buddy or participation in a local organization or class, can bring a much-needed sense of belonging and purpose.

Finding purpose by volunteering

Did you realize that giving back might improve your mental health? Volunteering not only helps you to make a positive difference in your community, but it also provides possibilities for social interaction and connection. Volunteering has been shown to reduce stress, improve emotional well-being, and even benefit our physical health. Whether you’re interested in environmental protection or helping local charities, volunteering may be a gratifying approach to combat loneliness while also making a difference in the world.

Seeking support for lasting solutions

If feelings of loneliness linger, seek professional help. Speaking with a health care expert, such as a therapist or psychologist, can provide helpful support, advice, and coping skills for loneliness. They can also assist uncover any underlying issues that may be contributing to your feelings of isolation and propose appropriate interventions based on your specific needs.

While there is no quick treatment for loneliness, you may take measures to increase meaningful connections and support in your life. Reaching out to people, emphasizing in-person interaction, volunteering, and seeking professional help as needed can help you break free from loneliness and embrace a life of purpose and connection.

The post Overcoming loneliness: 4 ways to make real connections and build community  first appeared on The Optimist Daily: Making Solutions the News.

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Successful Gene-Hacked Pig Kidney Transplant Shows Promise In Xenotransplantation | The Optimist Daily

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A team at Massachusetts General Hospital in Boston performed a breakthrough surgical accomplishment, transplanting a kidney from a gene-hacked pig into a 62-year-old man. Richard Slayman, a patient who suffered from kidney illness for almost a decade, emerged from the hospital with renewed optimism and health. 

“This moment—leaving the hospital today with one of the cleanest bills of health I’ve had in a long time—is one I wished would come for many years,” expressed Slayman in an official statement.

His transplanted kidney, created by biotech company eGenesis, is operating well, marking a big victory for xenotransplantation.

The promise of xenotransplantation

Xenotransplantation, or the process of transferring organs from one species to another, has enormous potential for alleviating the current shortage of human donor organs. David Klassen, chief medical officer of the United Network for Organ Sharing who was not involved in the surgery, emphasizes that this development can potentially benefit a large number of patients. 

“Though much work remains to be done, I think the potential of this to benefit a large number of patients will be realized, and that was a question mark hovering over the field,” he says. He hopes that these advancements will reduce the load on the organ donation system and provide life-saving treatments to individuals in need by using genetically engineered pig organs.

Overcoming challenges and uncertainties

Slayman’s successful operation is cause for excitement, but hurdles and uncertainty remain. The possibility of organ rejection exists, as Slayman’s immune system may still see the pig kidney as foreign. However, the rapid reversal of initial rejection symptoms with treatment provides a glimpse of optimism. Furthermore, the scalability and reproducibility of this technique have yet to be determined, raising concerns regarding its wider applicability to varied patient populations.

The future of organ transplantation

Despite these difficulties, the consequences of Slayman’s procedure are significant. With over 100,000 Americans waiting for human donor transplants each year and only a minority receiving them, demand significantly outstrips supply. By adopting xenotransplantation, we can change the field of organ transplantation, providing hope to many people on transplant waiting lists. Slayman’s rehabilitation journey is still ongoing, but his tale serves as a light of hope for sufferers around the world.

As Slayman begins his post-transplant journey, he is continuously followed and supported by medical personnel. His experience demonstrates the potential of innovation in medicine. With ongoing research and improvements in xenotransplantation, we are on the verge of a transformative age in healthcare.

The post Successful gene-hacked pig kidney transplant shows promise in xenotransplantation  first appeared on The Optimist Daily: Making Solutions the News.

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