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An Easy Hack To Counteract The Harmful Health Effects Of Sitting All Day | The Optimist Daily

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Full length shot of casually dressed young man working on laptop in modern open plan office sitting on orange circular sofa

Humans are not designed to spend the entire day seated. Nonetheless, billions of us do it at least five days per week, as Western work patterns dictate.

The health consequences of remaining on our bums all day are significant. According to studies, those who sit for extended durations are more likely to develop chronic diseases such as cancer, heart disease, and diabetes. Even daily bursts of exercise are not necessarily a cure for lengthy periods of desk work, despite their value.

The UK’s National Health Service (NHS) acknowledges that there is insufficient data to establish a daily restriction on the amount of time people should spend sitting. 

Fortunately, academics at Columbia University in the United States are attempting to fill this gap in the research. They intended to find out how to limit the hazards of sitting all day without having to do anything extreme like quit your work.

The resulting study, led by Keith Diaz, associate professor of behavioral medicine, was admittedly modest in size. Only 11 adults participated. Still, it offers a launching pad for further research.

What’s the bare minimum that we have to walk to offset health effects? 

Over the course of five days, each participant was asked to sit in a lab for eight hours, mimicking a regular workday. On one of those days, participants sat all day, only getting up to use the restroom. Diaz and his crew tested a variety of various walking tactics on the others to break up the sitting.

“Our goal was to find the least amount of walking one could do to offset the harmful health effects of sitting,” Diaz wrote for The Conversation in a blog post. “In particular, we measured changes in blood sugar levels and blood pressure, two important risk factors for heart disease.”

According to their results, the only method that effectively reduced blood sugar levels was a five-minute light walk every half-hour, which reduced the blood sugar surge after eating by over 60 percent when compared to sitting down.

During the study, researchers also used a questionnaire to ask participants to score their mental health.

“We found that compared with sitting all day, a five-minute light walk every half-hour reduced feelings of fatigue, put participants in a better mood, and helped them feel more energized,” he wrote. “We also found that even walks just once every hour were enough to boost mood and reduce feelings of fatigue.”

Short and frequent or long and infrequent?

More research is needed, but the results agree with advice from the UK government’s Health and Safety Executive, which suggests “short breaks often, rather than longer ones less often”. It recommends five to ten minutes every hour.

Diaz and his colleagues are currently studying additional ways for mitigating the health risks of extended sitting, particularly for people who can’t just get out of their seats, such as cab drivers.

“Finding alternative strategies that yield comparable results can provide the public with several different options, and ultimately allow people to pick the strategy that works best for them and their lifestyle,” said Diaz.

Source study: Medicine & Science in Sports & Exercise— Breaking up prolonged sitting to improve cardio metabolic risk: Dose-response analysis of a randomized cross-over trial

The post An easy hack to counteract the harmful health effects of sitting all day first appeared on The Optimist Daily: Making Solutions the News.

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These Are The World’s Happiest Countries, According To New Research

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What Went Right This Week: How The World Got Kinder, And More Good News

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Universal Cancer Immunotherapy May Be Possible Through Protein Engineering | The Optimist Daily

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Oncology medicine and cancer treatment concept as a tumor or tumour being treated with white blood cells attacking the disease as an immunotherapy 3D illustration.

Scientists at ETH Zurich have made significant progress in developing a ready-to-use immunotherapy treatment for cancer. A synthetic protein modification can allow immune cells from any donor to be delivered to any patient without the risk of an adverse immunological reaction.

What is immunotherapy?

The human immune system is a robust first line of defense against disease, but cancer has a few sneaky tricks up its sleeve that allow it to hide and avoid elimination. Immunotherapy is a new treatment that gives the immune system the upper hand by supercharging a patient’s immune cells to seek out and destroy cancers.

Typically, the approach involves extracting a patient’s immune cells, genetically modifying them to spot cancer, and reintroducing them into the body. Not only does this require time, which many cancer patients lack, but it isn’t always practical if a patient’s immune system isn’t up to the task.

Immune cells from a healthy patient would be ideal, but this comes with its own set of challenges. Because immune cells are adept at recognizing and attacking “foreign” cells, donated cells frequently end up targeting the recipient’s healthy cells.

What is TCR-CD3?

The ETH Zurich researchers discovered a solution to potentially overcome this obstacle in the latest study, paving the path for standardized, off-the-shelf immunotherapy. The researchers focused on a specific chemical combination known as TCR-CD3, located on the surface of killer T cells, and activate them towards specific antibodies – including both desired triggers such as cancer and unwanted ones on healthy cells.

The researchers developed a synthetic version of the TCR-CD3 complex that prevents killer T cells from attacking healthy cells while yet allowing them to be modified to target cancer cells. So far, laboratory tests on human cells have been positive, with no signs of harmful immunological responses.

While there is still much work to be done, such as testing in human patients, the team believes that the research will eventually lead to a standardized, off-the-shelf cancer therapy product that can be administered to any patient without the need to remove, engineer, and return their own immune cells. This would make it far less expensive, simpler, and faster to roll out to patients.

The researchers have applied for patents and intend to establish a spin-off company to assist in bringing the approach to the market.

The post Universal cancer immunotherapy may be possible through protein engineering first appeared on The Optimist Daily: Making Solutions the News.

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